BDBM50151357 2-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine::2-(3-Pyridin-2-yl-1H-pyrazol-4-yl)-[1,5]naphthyridine::CHEMBL183354

SMILES c1[nH]nc(c1-c1ccc2ncccc2n1)-c1ccccn1

InChI Key InChIKey=QDSPBHAERPGZFL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50151357   

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151357(2-(3-Pyridin-2-yl-1H-pyrazol-4-yl)-[1,5]naphthyrid...)
Affinity DataIC50: 50nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151357(2-(3-Pyridin-2-yl-1H-pyrazol-4-yl)-[1,5]naphthyrid...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151357(2-(3-Pyridin-2-yl-1H-pyrazol-4-yl)-[1,5]naphthyrid...)
Affinity DataIC50: 30nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.029-0.032)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151357(2-(3-Pyridin-2-yl-1H-pyrazol-4-yl)-[1,5]naphthyrid...)
Affinity DataIC50: 19nMAssay Description:Inhibition of TGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed