BDBM50151352 5-(6-Methyl-[1,5]naphthyridin-4-yl)-4-pyridin-2-yl-thiazol-2-ylamine::5-(6-methyl-1,5-naphthyridin-4-yl)-4-(pyridin-2-yl)thiazol-2-amine::CHEMBL425177

SMILES Cc1ccc2nccc(-c3sc(N)nc3-c3ccccn3)c2n1

InChI Key InChIKey=QXPCZCMDSKNVRW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50151352   

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151352(5-(6-methyl-1,5-naphthyridin-4-yl)-4-(pyridin-2-yl...)
Affinity DataIC50: 260nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151352(5-(6-methyl-1,5-naphthyridin-4-yl)-4-(pyridin-2-yl...)
Affinity DataIC50: 380nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.180-0.790)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151352(5-(6-methyl-1,5-naphthyridin-4-yl)-4-(pyridin-2-yl...)
Affinity DataIC50: 380nMAssay Description:Inhibition of TGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed