BDBM50151348 4-(pyridin-2-yl)-5-(quinolin-4-yl)thiazol-2-amine::4-Pyridin-2-yl-5-quinolin-4-yl-thiazol-2-ylamine::CHEMBL181640

SMILES Nc1nc(c(s1)-c1ccnc2ccccc12)-c1ccccn1

InChI Key InChIKey=UPYLCJSMNYCTLZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50151348   

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151348(4-Pyridin-2-yl-5-quinolin-4-yl-thiazol-2-ylamine |...)
Affinity DataIC50: 420nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151348(4-Pyridin-2-yl-5-quinolin-4-yl-thiazol-2-ylamine |...)
Affinity DataIC50: 720nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.095-5.521)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151348(4-Pyridin-2-yl-5-quinolin-4-yl-thiazol-2-ylamine |...)
Affinity DataIC50: 274nMAssay Description:Inhibition of TGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed