BDBM50151244 CHEMBL3770688

SMILES Cc1cc(ccc1N1CCN(CC1)S(=O)(=O)N[C@H](CCCNC(=O)OCc1ccccc1)C(=O)NO)C#N

InChI Key InChIKey=FWILDXURZVZYSC-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50151244   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ADAM-17 in human L428 cells assessed as reduction in pervanadate-induced soluble ALCAM shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of recombinant human ADAM-10 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ADAM-17 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble ALCAM shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human MMP-14 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of recombinant human MMP-9 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 370nMAssay Description:Inhibition of recombinant human MMP-2 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human MMP-1 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed