BDBM50150998 ((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzyl}-amino)-acetic acid::2-[(4-methoxyphenoxycarbonyl)({3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}methyl)amino]acetic acid::2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}methyl)amino]acetic acid::CHEMBL186179::MURAGLITAZAR::MURAGLITAZAR CHLORIDE::[C14]-2-((4-methoxyphenoxy)carbonyl)acetic acid

SMILES COc1ccc(OC(=O)N(CC(O)=O)Cc2ccc(OCCc3nc(oc3C)-c3ccccc3)cc2)cc1

InChI Key InChIKey=IRLWJILLXJGJTD-UHFFFAOYSA-N

Data  8 IC50  19 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50150998   

TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataIC50: 250nMAssay Description:Binding affinity at human PPARalpha by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataIC50: 120nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  3nMAssay Description:Transactivation of human Gal4-fused PPARgamma LBD expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  595nMAssay Description:Transactivation of human Gal4-fused PPARalpha LBD expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  300nMAssay Description:Agonist activity at GAL4-fused PPARalpha assessed as transcriptional activity by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at GAL4-fused PPARgamma assessed as transcriptional activity by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataIC50: 188nMAssay Description:Binding affinity at PPAR alpha receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataIC50: 1.41E+3nMAssay Description:Agonist activity at PPAR gamma in human HEK cells by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataIC50: 247nMAssay Description:Binding affinity at PPAR gamma receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  35nMAssay Description:Agonist activity at PPAR alpha in human HEK cells by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human PPARgamma transactivation expressed in human HePG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human PPARalpha transactivation expressed in human HePG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human PPARgamma expressed in HEK293 cells assessed as luciferase activity by GAL4 transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  1.41E+3nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as luciferase activity by GAL4 transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  240nMAssay Description:Effective concentration against human peroxisome proliferator activated receptor alpha in Gal4 transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataIC50: 190nMAssay Description:Binding affinity at human PPARalpha by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  1.41E+3nMAssay Description:Binding affinity to PPARalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  35nMAssay Description:Binding affinity to PPARgamma by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  153nMAssay Description:Agonist activity at human PPARgamma expressed in african green monkey CV-1 co-transfected with GAL4 by by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  4.11E+3nMAssay Description:Agonist activity at human PPARalpha expressed in african green monkey CV-1 by co-transfected with GAL4 by by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  110nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  320nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  35nMAssay Description:Agonist activity at GAL4 tagged human PPARgamma ligand binding domain expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2016
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  1.41E+3nMAssay Description:Agonist activity at GAL4 tagged human PPARalpha ligand binding domain expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2016
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50150998(2-[(4-methoxyphenoxycarbonyl)({4-[2-(5-methyl-2-ph...)
Affinity DataEC50:  120nMAssay Description:Effective concentration against human peroxisome proliferator activated receptor gamma in Gal4 transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed