BDBM50149825 2-Amino-6-(2-cyclopropylmethoxy-6-hydroxy-phenyl)-1'',2'',3'',4'',5'',6''-hexahydro-[4,4'']bipyridinyl-3-carbonitrile::CHEMBL368427

SMILES Nc1nc(cc(C2CCNCC2)c1C#N)-c1c(O)cccc1OCC1CC1

InChI Key InChIKey=DYVFBWXIOCLHPP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50149825   

LigandPNGBDBM50149825(2-Amino-6-(2-cyclopropylmethoxy-6-hydroxy-phenyl)-...)
Affinity DataIC50: 250nMAssay Description:Inhibition of I-kappa-B-kinase alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Kyoto 619-0216

Curated by ChEMBL
LigandPNGBDBM50149825(2-Amino-6-(2-cyclopropylmethoxy-6-hydroxy-phenyl)-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Syk protein tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50149825(2-Amino-6-(2-cyclopropylmethoxy-6-hydroxy-phenyl)-...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50149825(2-Amino-6-(2-cyclopropylmethoxy-6-hydroxy-phenyl)-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of I-kappa-B-kinase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed