BDBM50149801 2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine::5-(2-Methyl-thiazol-4-ylethynyl)-2-phenyl-pyridine::CHEMBL184995

SMILES Cc1nc(cs1)C#Cc1ccc(nc1)-c1ccccc1

InChI Key InChIKey=OUYHNXKLIHUODF-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50149801   

TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50149801(5-(2-Methyl-thiazol-4-ylethynyl)-2-phenyl-pyridine...)
Affinity DataIC50: 0.5nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50149801(5-(2-Methyl-thiazol-4-ylethynyl)-2-phenyl-pyridine...)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50149801(5-(2-Methyl-thiazol-4-ylethynyl)-2-phenyl-pyridine...)
Affinity DataKi:  2nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50149801(5-(2-Methyl-thiazol-4-ylethynyl)-2-phenyl-pyridine...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed