BDBM50148925 CHEMBL3770806

SMILES CCNc1ncc2cc(-c3ccc(cc3Cl)-c3cncc(C)n3)c(=O)n(CCCO)c2n1

InChI Key InChIKey=ICNMDSYSAGMRJC-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50148925   

TargetSerine/threonine-protein kinase PAK 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50148925(CHEMBL3770806)
Affinity DataIC50: 980nMAssay Description:Inhibition of PAK1 in human EBC1 cells assessed as reduction in levels of MEK phosphorylation at S298 residue after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50148925(CHEMBL3770806)
Affinity DataKi:  64nMAssay Description:Inhibition of human recombinant PAK1 kinase domain using coumarin/fluorescein-labeled FRET peptide as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed