BDBM50148690 4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-phenyl)-oxazol-2-yl]-piperidin-4-ol::CHEMBL121405

SMILES OC1(CCNCC1)c1nc(c(o1)-c1ccnc(NC2CCCCC2)c1)-c1ccc(F)cc1

InChI Key InChIKey=SAMLUEXYGUANPP-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50148690   

TargetCytochrome P450 2C9(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human cyclin-dependent kinase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human c-Jun N-terminal kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human Epidermal growth factor receptor, HER-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human c-Kit kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human c-Jun N-terminal kinase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human c-AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Met proto-oncogene tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human prostaglandin G/H synthase 1, COX-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human Epidermal growth factor receptor, HER-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed