BDBM50147748 1-{1-[1-(9H-Fluoren-2-yl)-ethyl]-piperidin-4-yl}-1,3-dihydro-indol-2-one::CHEMBL328411

SMILES CC(N1CCC(CC1)N1C(=O)Cc2ccccc12)c1ccc-2c(Cc3ccccc-23)c1

InChI Key InChIKey=QPOLDKMLCWYJNP-UHFFFAOYSA-N

Data  3 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50147748   

TargetNociceptin receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50147748(1-{1-[1-(9H-Fluoren-2-yl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataEC50: >1.00E+4nMAssay Description:Concentration required for stimulation of [35S]GTP-gamma-S, binding to human Nociceptin receptor in cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50147748(1-{1-[1-(9H-Fluoren-2-yl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataKi:  20nMAssay Description:Binding affinity against human Opioid receptor mu 1 on CHO cell membranes was determined by [3H]DAMGO displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50147748(1-{1-[1-(9H-Fluoren-2-yl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataKi:  74nMAssay Description:Binding affinity against human Opioid receptor kappa 1 on CHO cell membranes by [3H]U-69593 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50147748(1-{1-[1-(9H-Fluoren-2-yl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataKi:  135nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed