BDBM50147745 1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-dihydro-indol-2-one::CHEMBL99738

SMILES CC(C)[C@H]1CC[C@@H](CC1)N1CCC(CC1)N1C(=O)Cc2ccccc12

InChI Key InChIKey=KZQZXGOXGSLNTB-UHFFFAOYSA-N

Data  4 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50147745   

TargetNociceptin receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50147745(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataEC50:  117nMAssay Description:Concentration required for stimulation of [35S]GTP-gamma-S, binding to human Nociceptin receptor in cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50147745(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human nociceptin receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50147745(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50147745(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataKi:  22nMAssay Description:Binding affinity against human Opioid receptor mu 1 on CHO cell membranes was determined by [3H]DAMGO displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50147745(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataKi:  71nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50147745(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataKi:  369nMAssay Description:Binding affinity against human Opioid receptor kappa 1 on CHO cell membranes by [3H]U-69593 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed