BDBM50146471 CHEMBL431226::N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-N-hydroxy-formamide

SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)CC(C2CCC3(CC2)OCCO3)N(O)C=O)c2ccccc2n1

InChI Key InChIKey=IDKUTWZTCGVYET-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50146471   

TargetMatrix metalloproteinase-17(Human)
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146471(N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(2-methyl...)
Affinity DataIC50: 220nMAssay Description:Inhibition of matrix metalloprotease-17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146471(N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(2-methyl...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146471(N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(2-methyl...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146471(N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(2-methyl...)
Affinity DataIC50: 280nMAssay Description:Inhibition of matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50146471(N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(2-methyl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146471(N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(2-methyl...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed