BDBM50143059 CHEMBL3758746

SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccc(C)cc2C1=O

InChI Key InChIKey=OFLFGTPTGVETJG-UHFFFAOYSA-N

Data  4 IC50  12 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50143059   

TargetCytochrome P450 1A2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu5 receptor by cell based calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50:  11nMAssay Description:Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50:  11.5nMAssay Description:Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50:  26nMAssay Description:Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGluR5 (unknown origin) by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50:  22nMAssay Description:Positive allosteric modulation of human mGluR1 in presence of EC20 concentration of glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR7 in presence of EC20 concentration of L-AP4 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGluR8 (unknown origin) by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGluR2 (unknown origin) by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGluR3 (unknown origin) by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50143059(CHEMBL3758746)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGluR6 (unknown origin) by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed