BDBM50142692 CHEMBL3759092

SMILES [H][C@]12Cc3ccc(O)cc3[C@](C)(CCN1CCC(=O)Nc1ccccc1)[C@H]2C

InChI Key InChIKey=VGNUFLUEYYNYCK-UHFFFAOYSA-N

Data  11 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50142692   

TargetDelta-type opioid receptor(Mouse)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataEC50:  1.26E+5nMAssay Description:Antagonist activity at DOR in CD1 mouse vas deferens assessed as pEC50 for DPDPE-induced inhibition of EFS-evoked contractions at 1 uM incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataEC50:  794nMAssay Description:Agonist activity at MOR in Dunkin-Hartley guinea pig ileum assessed as inhibition of EFS-induced contractions incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2017
Entry Details Article
PubMed
TargetKappa-type/Mu-type opioid receptor(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataIC50: 1.90nMAssay Description:Agonist activity at MOR/KOR in Dunkin-Hartley guinea pig ileum assessed as inhibition of electrically induced contractions after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataKi:  0.830nMAssay Description:Binding affinity at mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]-DAMGO from MOR in rat brain membranes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]DAMGO from MOR in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataKi:  29nMAssay Description:Binding affinity at delta opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]-DPDPE from DOR in rat brain membranes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]DPDPE from human DOR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]-DPN from rat DOR expressed in EE-HEK293 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]-DPN from rat MOR expressed in EE-HEK293 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2017
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]-(+)-U69,593 from KOR in guinea pig brain membranes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]U69593 from rat KOR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50142692(CHEMBL3759092)
Affinity DataKi:  7.50E+3nMAssay Description:Activity at human KOR expressed in EE-HEK293 cells assessed as pEC50 for effect on (-)U50,488H-induced response (Rvb = 6.2 +/- 0.04 No_unit)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2017
Entry Details Article
PubMed