BDBM50142318 CHEMBL428651::{[2-Chloro-4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-difluoro-methyl}-phosphonic acid

SMILES OP(O)(=O)C(F)(F)c1ccc(CC(C(=O)c2ccccc2)c2ccccc2)cc1Cl

InChI Key InChIKey=PRIBWEDDPMECKZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50142318   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142318({[2-Chloro-4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-d...)
Affinity DataIC50: 360nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142318({[2-Chloro-4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-d...)
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142318({[2-Chloro-4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-d...)
Affinity DataIC50: 2.40E+3nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142318({[2-Chloro-4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-d...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142318({[2-Chloro-4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-d...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CD45 (564 to 12687 residues) expressed in Escherichia coli using FDP as substrate incubated for 10 minMore data for this Ligand-Target Pair
In DepthDetails
PubMed