BDBM50142314 CHEMBL267022::difluoro(4-(3-oxo-2,3-diphenylpropyl)phenyl)methylphosphonic acid::{Difluoro-[4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-methyl}-phosphonic acid

SMILES OP(O)(=O)C(F)(F)c1ccc(CC(C(=O)c2ccccc2)c2ccccc2)cc1

InChI Key InChIKey=XZLQCWJPAKCNQB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50142314   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142314({Difluoro-[4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-m...)
Affinity DataIC50: 1.60E+4nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142314({Difluoro-[4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-m...)
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142314({Difluoro-[4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-m...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142314({Difluoro-[4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-m...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PTP1B by fluorescein diphosphate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142314({Difluoro-[4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-m...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CD45 by fluorescein diphosphate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed