BDBM50142311 CHEMBL266056::[(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-oxo-2,3-diphenyl-propyl}-phenyl)-difluoro-methyl]-phosphonic acid

SMILES OP(O)(=O)C(F)(F)c1ccc(CC(Cc2ccc(cc2)C(F)(F)P(O)(O)=O)(C(=O)c2ccccc2)c2ccccc2)cc1

InChI Key InChIKey=IZDWSIZSMHRZPZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50142311   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311([(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-ox...)
Affinity DataIC50: 580nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311([(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-ox...)
Affinity DataIC50: 580nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311([(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-ox...)
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311([(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-ox...)
Affinity DataIC50: 60nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311([(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-ox...)
Affinity DataIC50: 60nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311([(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-ox...)
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311([(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-ox...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311([(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-ox...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CD45 (564 to 12687 residues) expressed in Escherichia coli using FDP as substrate incubated for 10 minMore data for this Ligand-Target Pair
In DepthDetails
PubMed