BDBM50141809 2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-methoxy-quinolin-7-yloxy}-ethylamino)-ethanol::CHEMBL352308

SMILES COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3)ccnc2cc1OCCNCCO

InChI Key InChIKey=VQCDZFWRGXFUMS-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50141809   

LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50: 480nMAssay Description:Inhibition of PDGF-receptor autophosphorylation in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF-receptor 1 autophosphorylation in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGF-receptor autophosphorylation in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Met autophosphorylation of in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50: 88nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50: 83nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2 autophosphorylation in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50: 100nMAssay Description:Inhibition of c-Kit autophosphorylation in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50: 69nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50: 69nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50: 69nMAssay Description:Inhibition of FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50: 69nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed