BDBM50140796 1-(2-Bromo-phenyl)-3-(4-cyano-2-hydroxy-phenyl)-urea::1-(2-bromophenyl)-3-(4-cyano-2-hydroxyphenyl)urea::CHEMBL27863

SMILES Oc1cc(ccc1NC(=O)Nc1ccccc1Br)C#N

InChI Key InChIKey=VIKJECVSALYBJB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50140796   

TargetC-X-C chemokine receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50140796(1-(2-Bromo-phenyl)-3-(4-cyano-2-hydroxy-phenyl)-ur...)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 1 expressed in CHO Cells using [125I]IL-8 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50140796(1-(2-Bromo-phenyl)-3-(4-cyano-2-hydroxy-phenyl)-ur...)
Affinity DataIC50: 25nMAssay Description:Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]IL-8 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50140796(1-(2-Bromo-phenyl)-3-(4-cyano-2-hydroxy-phenyl)-ur...)
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed