BDBM50140386 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-dimethylaminomethyl-3-fluoro-biphenyl-4-yl)-amide::CHEMBL277949

SMILES CN(C)Cc1ccccc1-c1ccc(NC(=O)c2cc(C)nn2-c2ccc3cc(Cl)ccc3c2)c(F)c1

InChI Key InChIKey=MTGLNKLJXIUNBV-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50140386   

TargetKallikrein-1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140386(2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibitory concentration of compound was determined against kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140386(2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against activated protein CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140386(2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against tissue type plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140386(2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Rat)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140386(2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against PlasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140386(2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibitory concentration of compound was determined against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140386(2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration against human Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140386(2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed