BDBM50140168 (E)-1-(2,4-dihydroxyphenyl)-3-(3-hydroxyphenyl)-2-propen-1-one (2)::(E)-3,2'',4''-Trihydroxychalcone::CHEMBL1083821

SMILES Oc1cccc(\C=C\C(=O)c2ccc(O)cc2O)c1

InChI Key InChIKey=WKMQGQZPDSFACZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50140168   

TargetBeta-secretase 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

LigandPNGBDBM50140168((E)-3,2'',4''-Trihydroxychalcone | CHEMBL1083821 |...)
Affinity DataIC50: 8.03E+3nMpH: 4.5 T: 2°CAssay Description:The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2017
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Bovine)
Northern Kentucky University

Curated by ChEMBL
LigandPNGBDBM50140168((E)-3,2'',4''-Trihydroxychalcone | CHEMBL1083821 |...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Bovine)
Northern Kentucky University

Curated by ChEMBL
LigandPNGBDBM50140168((E)-3,2'',4''-Trihydroxychalcone | CHEMBL1083821 |...)
Affinity DataIC50: 1.08E+5nMAssay Description:Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed