BDBM50140102 3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione::CHEMBL23729

SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)NCc2ccccc2)c1=O

InChI Key InChIKey=OGZRDFCFZJLDGT-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50140102   

TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140102(3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzy...)
Affinity DataIC50: 38nMAssay Description:In vitro inhibition of [Ca2+] influx in RBL cells expressing Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140102(3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzy...)
Affinity DataKi:  25nMAssay Description:Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140102(3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzy...)
Affinity DataKi:  51nMAssay Description:Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140102(3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzy...)
Affinity DataKi:  550nMAssay Description:In vivo inhibition of monkey Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140102(3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzy...)
Affinity DataKi:  2.50E+4nMAssay Description:In vivo inhibition of rat Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed