BDBM50139897 CHEMBL3764830::US10577361, E33

SMILES Cn1c(SCCCN2CCOC(C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccc(cc1)S(N)(=O)=O

InChI Key InChIKey=UOTFFOLRZJNLDZ-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50139897   

TargetD(3) dopamine receptor(Rat)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50139897(CHEMBL3764830 | US10577361, E33)
Affinity DataKi:  126nMAssay Description:Displacement of [125I]-7-OH-PIPAT from rat brain dopamine D3 receptor after 45 mins by microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM50139897(CHEMBL3764830 | US10577361, E33)
Affinity DataKi:  135nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetD(3) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM50139897(CHEMBL3764830 | US10577361, E33)
Affinity DataKi: <1.00E+4nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells after 90 mins by [35S]-GTPgamma S assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50139897(CHEMBL3764830 | US10577361, E33)
Affinity DataKi: <3.16E+4nMAssay Description:Displacement of [125I]-7-OH-PIPAT from rat brain dopamine D2 receptor after 45 mins by microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50139897(CHEMBL3764830 | US10577361, E33)
Affinity DataKi: >3.16E+4nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were re-suspended ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent