BDBM50139355 2-(6-Phenylpyridin-2-ylthio)-N,N-dimethylethan-amine::CHEMBL161765::Dimethyl-[2-(6-phenyl-pyridin-2-ylsulfanyl)-ethyl]-amine

SMILES CN(C)CCSc1cccc(n1)-c1ccccc1

InChI Key InChIKey=KYRANNSMDBEVPQ-UHFFFAOYSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50139355   

Target5-hydroxytryptamine receptor 7(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139355(Dimethyl-[2-(6-phenyl-pyridin-2-ylsulfanyl)-ethyl]...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139355(Dimethyl-[2-(6-phenyl-pyridin-2-ylsulfanyl)-ethyl]...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139355(Dimethyl-[2-(6-phenyl-pyridin-2-ylsulfanyl)-ethyl]...)
Affinity DataKi:  0.600nMAssay Description:Antagonist activity at 5-HT7 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139355(Dimethyl-[2-(6-phenyl-pyridin-2-ylsulfanyl)-ethyl]...)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139355(Dimethyl-[2-(6-phenyl-pyridin-2-ylsulfanyl)-ethyl]...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1A receptor by the displacement of [3H]5-HT radioligand from the cloned receptor expressed in HeLa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139355(Dimethyl-[2-(6-phenyl-pyridin-2-ylsulfanyl)-ethyl]...)
Affinity DataKi:  16nMAssay Description:Antagonist activity at 5-HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50139355(Dimethyl-[2-(6-phenyl-pyridin-2-ylsulfanyl)-ethyl]...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139355(Dimethyl-[2-(6-phenyl-pyridin-2-ylsulfanyl)-ethyl]...)
Affinity DataKi:  320nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 2A receptor by the displacement of [3H]ketanserin radioligand from the cloned receptor expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139355(Dimethyl-[2-(6-phenyl-pyridin-2-ylsulfanyl)-ethyl]...)
Affinity DataKi:  450nMAssay Description:Binding affinity towards human dopamine receptor D2 by the displacement of [3H]spiperone radioligand from the cloned receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed