BDBM501362 US11021511, Compound 6a

SMILES CO[C@@H]1[C@H]2CO[P@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12

InChI Key InChIKey=YKGVBWQDPFBQET-UHFFFAOYSA-N

Data  1 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 501362   

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501362(US11021511, Compound 6a)
Affinity DataIC50: 10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501362(US11021511, Compound 6a)
Affinity DataEC50:  53nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501362(US11021511, Compound 6a)
Affinity DataKd:  6nMAssay Description:Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent