BDBM50136008 12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[4,3-c]carbazol-5-one::CHEMBL150894

SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1

InChI Key InChIKey=MLIFNJABMANKEU-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50136008   

LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant Tie2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 406nMAssay Description:Inhibition of Platelet-derived growth factor receptor betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 57nMAssay Description:Inhibition of Proto-oncogene tyrosine-protein kinase KitMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of TrkA receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 162nMAssay Description:Inhibition of Fibroblast growth factor receptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Tyrosine protein kinase receptor TIE-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Tyrosine-protein kinase receptor FLT3 (fms-related tyrosine kinase 3) receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Serine/threonine-protein kinase Chk2 (CDS1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 448nMAssay Description:Inhibition of c-Jun N-terminal kinase 1-beta 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of beta-insulin receptor kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha/beta/gamma type(Rat)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat brain Protein kinase CMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Serine/threonine-protein kinase Chk1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed