BDBM50135483 1-(6-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)-3-methyl-pyrrole-2,5-dione::1-(6-methoxy-2-(thiophen-2-yl)quinazolin-4-ylamino)-3-methyl-1H-pyrrole-2,5-dione::CHEMBL337665

SMILES COc1ccc2nc(nc(NN3C(=O)C=C(C)C3=O)c2c1)-c1cccs1

InChI Key InChIKey=WAPBQFRODQBNJI-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50135483   

TargetTranscription factor Jun(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50135483(1-(6-methoxy-2-(thiophen-2-yl)quinazolin-4-ylamino...)
Affinity DataIC50: 3nMAssay Description:Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetTranscription factor p65(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50135483(1-(6-methoxy-2-(thiophen-2-yl)quinazolin-4-ylamino...)
Affinity DataEC50:  4.20E+4nMAssay Description:Potentiation of TNF-alpha-induced NF-kappaB p65 nuclear translocation in HUVEC cells by immunostainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTranscription factor p65(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50135483(1-(6-methoxy-2-(thiophen-2-yl)quinazolin-4-ylamino...)
Affinity DataEC50:  9.80E+3nMAssay Description:Induction of NF-kappaB p65 nuclear translocation in HUVEC cells by immunostainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed