BDBM50134807 3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]pyrimidin-(4E)-ylideneamine::CHEMBL355905

SMILES CSc1nc2ccccn2c(=N)c1S(=O)(=O)c1ccccc1

InChI Key InChIKey=PUHRPYOPXGWCTE-UHFFFAOYSA-N

Data  1 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50134807   

TargetAromatase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134807(3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]py...)
Affinity DataIC50: 860nMAssay Description:Inhibition of recombinant human Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134807(3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]py...)
Affinity DataIC50: 2.42E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134807(3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]py...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 3A4 with BzResMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134807(3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]py...)
Affinity DataIC50: 4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 6 receptor using [3H]- LSD as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134807(3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]py...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134807(3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]py...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134807(3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]py...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 3A4 with BFCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134807(3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]py...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134807(3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]py...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]LSD from human cloned 5-HT6 receptor expressed in HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134807(3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]py...)
Affinity DataKi:  4nMAssay Description:Binding affinity for human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article
PubMed