BDBM50133525 CHEMBL115643::N-((trans-4-aminocyclohexyl)methyl)-2-(6-methyl-2-oxo-3-(phenylmethylsulfonamido)pyridin-1(2H)-yl)acetamide::N-(4-Amino-cyclohexylmethyl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide

SMILES Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)NC[C@H]1CC[C@H](N)CC1

InChI Key InChIKey=GXHLOSIMIREONN-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50133525   

TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133525(N-(4-Amino-cyclohexylmethyl)-2-(6-methyl-2-oxo-3-p...)
Affinity DataKi:  4.60nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133525(N-(4-Amino-cyclohexylmethyl)-2-(6-methyl-2-oxo-3-p...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133525(N-(4-Amino-cyclohexylmethyl)-2-(6-methyl-2-oxo-3-p...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity was evaluated against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133525(N-(4-Amino-cyclohexylmethyl)-2-(6-methyl-2-oxo-3-p...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133525(N-(4-Amino-cyclohexylmethyl)-2-(6-methyl-2-oxo-3-p...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity against human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article