BDBM50133384 Anilinoquinazoline, 4a::CHEMBL336113::N*4*-m-Tolyl-quinazoline-4,6-diamine::N4-(3-methylphenyl)-4,6-quinazolinediamine

SMILES Cc1cccc(Nc2ncnc3ccc(N)cc23)c1

InChI Key InChIKey=NFBCSWGEYDCCDW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50133384   

TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

LigandPNGBDBM50133384(N4-(3-methylphenyl)-4,6-quinazolinediamine | Anili...)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:EGFR kinase assay was perform using Nunc MaxiSorp purchased from Nalge Nunc Interantional.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

LigandPNGBDBM50133384(N4-(3-methylphenyl)-4,6-quinazolinediamine | Anili...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133384(N4-(3-methylphenyl)-4,6-quinazolinediamine | Anili...)
Affinity DataIC50: 6.39E+3nMAssay Description:Inhibition of serum-stimulated proliferation of mouse ERBB2 transfected NIH3T3 cell line after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

LigandPNGBDBM50133384(N4-(3-methylphenyl)-4,6-quinazolinediamine | Anili...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed