BDBM50133382 Anilinoquinazoline, 4c::CHEMBL343352::N*4*-(3-Chloro-phenyl)-quinazoline-4,6-diamine::N4-(3-chlorophenyl)-4,6-quinazolinediamine::N4-(3-chlorophenyl)quinazoline-4,6-diamine

SMILES Nc1ccc2ncnc(Nc3cccc(Cl)c3)c2c1

InChI Key InChIKey=AWAYNEMCHILZCF-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50133382   

TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

LigandPNGBDBM50133382(CHEMBL343352 | N4-(3-chlorophenyl)-4,6-quinazoline...)
Affinity DataIC50: 200nMT: 2°CAssay Description:EGFR kinase assay was perform using Nunc MaxiSorp purchased from Nalge Nunc Interantional.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

LigandPNGBDBM50133382(CHEMBL343352 | N4-(3-chlorophenyl)-4,6-quinazoline...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

LigandPNGBDBM50133382(CHEMBL343352 | N4-(3-chlorophenyl)-4,6-quinazoline...)
Affinity DataIC50: 200nMAssay Description:Inhibition of poly(L-glutamic acid-L-tyrosine) phosphorylation by EGFR tyrosine kinase of A431 carcinoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133382(CHEMBL343352 | N4-(3-chlorophenyl)-4,6-quinazoline...)
Affinity DataIC50: 3.29E+3nMAssay Description:Inhibition of serum-stimulated proliferation of mouse ERBB2 transfected NIH3T3 cell line after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

LigandPNGBDBM50133382(CHEMBL343352 | N4-(3-chlorophenyl)-4,6-quinazoline...)
Affinity DataIC50: 200nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

LigandPNGBDBM50133382(CHEMBL343352 | N4-(3-chlorophenyl)-4,6-quinazoline...)
Affinity DataIC50: 200nMAssay Description:Inhibition of EGFR tyrosine kinase expressed in A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

LigandPNGBDBM50133382(CHEMBL343352 | N4-(3-chlorophenyl)-4,6-quinazoline...)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant EGFR expressed in baculovirus infected Sf9 cells after 1 hr by DELFIA/time-resolved fluorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

LigandPNGBDBM50133382(CHEMBL343352 | N4-(3-chlorophenyl)-4,6-quinazoline...)
Affinity DataIC50: 189nMAssay Description:Inhibition of EGFR after 50 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

LigandPNGBDBM50133382(CHEMBL343352 | N4-(3-chlorophenyl)-4,6-quinazoline...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant human GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed