BDBM50133368 CHEMBL335950::N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-2-(naphthalen-1-yl)acetamide::N-[2-Furan-2-yl-8-(3-phenyl-propyl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-2-naphthalen-1-yl-acetamide

SMILES O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(nn12)-c1ccco1

InChI Key InChIKey=OOTVLKSCGYKBDY-UHFFFAOYSA-N

Data  12 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50133368   

TargetAdenosine receptor A2b(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2b(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2b(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2b(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2b(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human adenosine A2b receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]MRE3008-F20 from human A3 receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Bovine)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  300nMAssay Description:Binding affinity to bovine adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  300nMAssay Description:Antagonist activity at human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  305nMAssay Description:Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  343nMAssay Description:Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  710nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  800nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [3H]DPCPX from human Adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50133368(N-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4...)
Affinity DataKi:  1.10E+3nMAssay Description:Binding affinity to human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed