BDBM50132992 4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)phenol::4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-phenol::CHEMBL118928

SMILES Cc1cccc(n1)-c1n[nH]cc1-c1ccc(O)cc1

InChI Key InChIKey=YOLJORSLLBNCFO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50132992   

TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132992(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-phen...)
Affinity DataIC50: 32nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132992(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-phen...)
Affinity DataIC50: 560nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132992(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-phen...)
Affinity DataIC50: 31nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132992(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-phen...)
Affinity DataIC50: 44nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132992(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-phen...)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132992(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-phen...)
Affinity DataIC50: 31nMAssay Description:Inhibition of TGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed