BDBM50132713 Arachidonic acid derivative::CHEMBL113262::Methyl arachidonoyl fluorophophonate::methyl ((5Z,8Z,11Z,14Z)-2-Icosa-5,8,11,14-tetraenyl)phosphonofluoridoate::methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenylphosphonofluoridate::methyl -icosa-5,8,11,14-tetraenylphosphonofluoridate::methyl(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenylphosphonofluoridate::methylarachidonyl fluorophosphonate

SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC

InChI Key InChIKey=KWKZCGMJGHHOKJ-UHFFFAOYSA-N

Data  18 IC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50132713   

TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 26.3nMAssay Description:Inhibition of human MGLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMonoacylglycerol lipase ABHD6(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 17nMAssay Description:Inhibition of ABHD6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 26.3nMAssay Description:Inhibition of human MGL activity using [3H]2-oleoylglycerol substrate by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 0.331nMAssay Description:Inhibition of human recombinant FAAH-maltose binding proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 1nMAssay Description:Inhibition of FAAHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 3nMAssay Description:Irreversible inhibition of fatty acid amide hydrolase; range=1-3 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytosolic phospholipase A2(Human)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 640nMAssay Description:Inhibition of cPLA2 from human platelets by RP-HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 23nMAssay Description:Inhibition of FAAH from rat brain microsomes by RP-HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFatty-acid amide hydrolase 1(Human)
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 2.5nMAssay Description:Inhibitory potency of Fatty-acid amide hydrolase with rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Human)
Shiv Nadar University

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 72nMAssay Description:Inhibition of PAFAH1B2 (unknown origin) using 2-thiol-PAF as substrate by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 26nMAssay Description:Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 60 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 28nMAssay Description:Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 90 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 25nMAssay Description:Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 30 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 25nMAssay Description:Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory potency of Fatty-acid amide hydrolase with Mouse brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 20nMAssay Description:Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with rat brain membrane in the presence of P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50132713(Methyl arachidonoyl fluorophophonate | methyl -ico...)
Affinity DataIC50: 530nMAssay Description:Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed