BDBM50132634 (2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-pyridin-3-ylmethoxy)-benzenesulfonyl]-piperazine-2-carboxylic acid hydroxyamide::CHEMBL110211

SMILES C[C@H]1[C@@H](N(CCN1C(C)=O)S(=O)(=O)c1ccc(OCc2cccnc2C)cc1)C(=O)NO

InChI Key InChIKey=HEJQAFMDGAOYSZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50132634   

LigandPNGBDBM50132634((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-pyridin-3...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132634((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-pyridin-3...)
Affinity DataIC50: 8nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132634((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-pyridin-3...)
Affinity DataIC50: 3.40E+3nMAssay Description:In vitro inhibition of matrix metalloprotease-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132634((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-pyridin-3...)
Affinity DataIC50: 800nMAssay Description:Inhibition of Tumor necrosis factor-alpha (TNF-alpha) release in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed