BDBM50131976 1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzothiazole-2-carbonyl)-4-guanidino-butyl]-amide; TFA::CHEMBL127185

SMILES CC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1

InChI Key InChIKey=ZEDMSBVBKUUZHF-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50131976   

TargetTryptase beta-2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131976(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity of compound was determined against human Tryptase betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetTrypsin-3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131976(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataIC50: 4nMAssay Description:Beta-Trypsin inhibitory activity of compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131976(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  960nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131976(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  1.40E+4nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed