BDBM50131843 CHEMBL3633152

SMILES COc1cc(OCCN(C)C)ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1

InChI Key InChIKey=RGZXAQQHXALOBL-UHFFFAOYSA-N

Data  1 IC50  12 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50131843   

TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of wild type EGFR phosphorylation in human A431 cells after 60 mins by mesoscale multiplex assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  320nMAssay Description:Competitive binding affinity to human BLK in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  290nMAssay Description:Competitive binding affinity to human BTK in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  220nMAssay Description:Competitive binding affinity to human wild type EGFR in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  0.960nMAssay Description:Competitive binding affinity to human EGFR T790M mutant in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  220nMAssay Description:Competitive binding affinity to human ERBB2 in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  130nMAssay Description:Competitive binding affinity to human ERBB4 in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-G-associated kinase(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  430nMAssay Description:Competitive binding affinity to human GAK in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  140nMAssay Description:Competitive binding affinity to human ITK in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  2.80E+3nMAssay Description:Competitive binding affinity to human JAK1 JH2 domain pseudokinase in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  30nMAssay Description:Competitive binding affinity to human JAK3 in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  81nMAssay Description:Competitive binding affinity to human TTK in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  410nMAssay Description:Competitive binding affinity to human TXK in presence of immobilized ligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed