BDBM50131841 CHEMBL3633143

SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(C)CC1

InChI Key InChIKey=VJQPNQROUWVJQN-UHFFFAOYSA-N

Data  4 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50131841   

TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131841(CHEMBL3633143)
Affinity DataIC50: 386nMAssay Description:Inhibition of wild type EGFR phosphorylation in human A431 cells after 60 mins by mesoscale multiplex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131841(CHEMBL3633143)
Affinity DataIC50: 330nMAssay Description:Inhibition of N-terminal 6His/TEV protease cleavage site-tagged wild type human EGFR using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131841(CHEMBL3633143)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) using Poly (Glu, Tyr)4:1 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRAC-alpha serine/threonine-protein kinase(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50131841(CHEMBL3633143)
Affinity DataEC50: >1.00E+3nMAssay Description:Induction of AKT1 degradation in human NCI-H1975 cells assessed as reduction in AKT1 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50131841(CHEMBL3633143)
Affinity DataEC50: >1.00E+3nMAssay Description:Induction of AKT2 degradation in human NCI-H1975 cells assessed as reduction in AKT2 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50131841(CHEMBL3633143)
Affinity DataEC50: >1.00E+3nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50131841(CHEMBL3633143)
Affinity DataIC50: 31nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed