BDBM50131813 CHEMBL3634599

SMILES CC(Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ccccn1

InChI Key InChIKey=PVGOQRJICUIPTG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50131813   

TargetKynurenine 3-monooxygenase(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50131813(CHEMBL3634599)
Affinity DataIC50: 4nMAssay Description:Inhibition of kynurenine monooxygenase (unknown origin) by MS rapidfire assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50131813(CHEMBL3634599)
Affinity DataIC50: 126nMAssay Description:Inhibition of full length human KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2020
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50131813(CHEMBL3634599)
Affinity DataIC50: 100nMAssay Description:Inhibition of KMO in human primary hepatocytes using kynurenine as substrate measured after overnight incubation by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2020
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50131813(CHEMBL3634599)
Affinity DataIC50: 125nMAssay Description:Inhibition of full length human KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2020
Entry Details Article
PubMed