BDBM50130648 CHEMBL432798::N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide

SMILES CSc1nc(c(-c2ccnc(NC(C)=O)c2)n1C)-c1ccc(F)cc1

InChI Key InChIKey=CJKGORBZVWDVRY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50130648   

TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50130648(N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfany...)
Affinity DataIC50: 188nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130648(N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfany...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibitory activity against TNF-alpha release in PBM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130648(N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfany...)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of p38-related TNF-alpha release by whole blood cells at 10 e-4 to 10 e-8 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130648(N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfany...)
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of p38-related IL1-beta release by whole blood cells at 10 e-4 to 10 e-8 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130648(N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfany...)
Affinity DataIC50: 75nMAssay Description:Inhibitory activity against induction of IL-1-beta release in PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130648(N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfany...)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 at 10 e-4 to 10 e-8 M concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
C-A-I-R Biosciences

Curated by ChEMBL
LigandPNGBDBM50130648(N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfany...)
Affinity DataIC50: 2.86E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50130648(N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfany...)
Affinity DataIC50: 500nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed