BDBM50130276 CHEMBL553794::N-Methyl-2-{2-[4-(2-oxo-1,2,4,5-tetrahydro-3H-benzo[cd]indol-2a-yl)-butyl]-1,2,3,4-tetrahydro-beta-carbolin-9-yl}-acetamide

SMILES CNC(=O)Cn1c2CN(CCCCC34CCCc5cccc(NC3=O)c45)CCc2c2ccccc12

InChI Key InChIKey=WTHVGNDEIMLIHE-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50130276   

Target5-hydroxytryptamine receptor 7(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50130276(N-Methyl-2-{2-[4-(2-oxo-1,2,4,5-tetrahydro-3H-benz...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50130276(N-Methyl-2-{2-[4-(2-oxo-1,2,4,5-tetrahydro-3H-benz...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50130276(N-Methyl-2-{2-[4-(2-oxo-1,2,4,5-tetrahydro-3H-benz...)
Affinity DataKi:  129nMAssay Description:In vitro binding affinity at human recombinant 5-hydroxytryptamine 1A receptor in mammalian cells using 3[H]8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50130276(N-Methyl-2-{2-[4-(2-oxo-1,2,4,5-tetrahydro-3H-benz...)
Affinity DataKi:  490nMAssay Description:In vitro binding affinity at 5-hydroxytryptamine 4 receptor in guinea pig striatum using 3[H]GR-113808 as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50130276(N-Methyl-2-{2-[4-(2-oxo-1,2,4,5-tetrahydro-3H-benz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity towards 5-HT2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50130276(N-Methyl-2-{2-[4-(2-oxo-1,2,4,5-tetrahydro-3H-benz...)
Affinity DataKi: <1.00E+3nMAssay Description:In vitro binding affinity at human recombinant 5-hydroxytryptamine 6 receptor in mammalian cells using 3[H]LSD as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50130276(N-Methyl-2-{2-[4-(2-oxo-1,2,4,5-tetrahydro-3H-benz...)
Affinity DataKi: <1.00E+3nMAssay Description:In vitro binding affinity at 5-hydroxytryptamine 2C receptor in pig choroid plexus using 3[H]mesulergine as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Mouse)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50130276(N-Methyl-2-{2-[4-(2-oxo-1,2,4,5-tetrahydro-3H-benz...)
Affinity DataKi: <1.00E+3nMAssay Description:In vitro binding affinity at 5-hydroxytryptamine 3 receptor in N1E-115 cells using 3[H]GR-65630 as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50130276(N-Methyl-2-{2-[4-(2-oxo-1,2,4,5-tetrahydro-3H-benz...)
Affinity DataKi: <1.00E+3nMAssay Description:In vitro binding affinity to 5-hydroxytryptamine 2 receptor of rat cerebral cortex membranes using [3H]ketanserin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50130276(N-Methyl-2-{2-[4-(2-oxo-1,2,4,5-tetrahydro-3H-benz...)
Affinity DataKi: <1.00E+3nMAssay Description:In vitro binding affinity at 5-hydroxytryptamine 1B receptor in rat striatal muscles using [125I](-)-iodocyanopindolol as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed