BDBM50129986 (4-Benzyl-benzyl)-[4-(4-chloro-phenyl)-2-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-butyl]-phosphinic acid::2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)carbamoyl)-4-(4-chlorophenyl)butyl(4-benzylbenzyl)phosphinic acid::CHEMBL77163

SMILES CNC(=O)[C@@H](NC(=O)C(CCc1ccc(Cl)cc1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C

InChI Key InChIKey=VAQVSMUJBPTVIS-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50129986   

TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 8.30nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 900nMAssay Description:Inhibition of matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed