BDBM50126764 (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid::2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)-propionic acid::3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE::CHEMBL28472

SMILES N[C@@H](CC1=CCCCc2o[nH]c(=O)c12)C(O)=O

InChI Key InChIKey=HJEPOXZLPHUVFE-UHFFFAOYSA-N

Data  7 KI  13 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50126764   

TargetGlutamate receptor ionotropic, kainate 5(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  130nMAssay Description:Electrophysiological data on Xenopus oocytes, expressing homomeric Ionotropic glutamate receptor ionotropic kainate 1 (GluR5)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  4.50E+3nMAssay Description:Agonist activity at ConA-treated rat GluR1 flip isoform expressed in Xenopus laevis oocytes assessed as glutamic acid-induced maximal current by two-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  130nMAssay Description:Agonist activity at ConA-treated rat GluR5(Q) RNA-edited isoform expressed in Xenopus laevis oocytes assessed as glutamic acid-induced maximal curren...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat recombinant GluR6(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  580nMAssay Description:Agonist activity at rat recombinant GluR5(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 4(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  6.70E+3nMAssay Description:Agonist activity at rat recombinant GluR4 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  1.30E+4nMAssay Description:Agonist activity at rat recombinant GluR3 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  9.20E+4nMAssay Description:Agonist activity at rat recombinant GluR2(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  3.20E+4nMAssay Description:Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  4.50E+3nMAssay Description:Electrophysiological data on Xenopus oocytes, expressing homomeric Ionotropic glutamate receptor AMPA 1 (GluR1o)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor(African clawed frog)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  6.40E+3nMAssay Description:Electrophysiological data on Xenopus oocytes, expressing heteromeric Ionotropic glutamate receptor ionotropic kainate 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 4(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  1.50E+4nMAssay Description:Electrophysiological data on Xenopus oocytes, expressing homomeric Ionotropic glutamate receptor AMPA 4 (GluR4o)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 3(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  7.20E+3nMAssay Description:Electrophysiological data on Xenopus oocytes, expressing homomeric Ionotropic glutamate receptor AMPA 3 (GluR3o)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataKi:  2.57nMAssay Description:Displacement of [3H]SYM from rat recombinant GluR5(Q) RNA-edited isoform expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataKi:  173nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR3 flop isoform expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataKi:  175nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR2(R) RNA-edited flop isoform expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataKi:  199nMAssay Description:Displacement of [3H]SYM from rat recombinant GluR7A expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 4(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataKi:  202nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR4 flop isoform expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataKi:  232nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR1 flop isoform expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]KA from rat recombinant GluR6(VCR) RNA-edited isoform expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed