BDBM50126024 4-[3-(5,3'-Dichloro-biphenyl-2-yl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-benzonitrile::CHEMBL277646

SMILES Cn1cncc1C(O)(C#Cc1ccc(Cl)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N

InChI Key InChIKey=AYVGITDSDRJQKI-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50126024   

LigandPNGBDBM50126024(4-[3-(5,3'-Dichloro-biphenyl-2-yl)-1-hydroxy-1-(3-...)
Affinity DataEC50:  100nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50126024(4-[3-(5,3'-Dichloro-biphenyl-2-yl)-1-hydroxy-1-(3-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human FTase-catalyzed incorporation of [3H]FPP into recombinant Ras CVIMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50126024(4-[3-(5,3'-Dichloro-biphenyl-2-yl)-1-hydroxy-1-(3-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human GGTase-catalyzed incorporation of [3H]GGPP into biotinylated peptide of C-terminal of human K-RasMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed