BDBM50124308 CHEMBL173484::N-{3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin-4-yl]-phenyl}-3-piperidin-1-yl-propionamide

SMILES Nc1nc(cc(-c2cccc(NC(=O)CCN3CCCCC3)c2)c1C#N)-c1ccccc1O

InChI Key InChIKey=OGKJHWSTJKFLOO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50124308   

LigandPNGBDBM50124308(N-{3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin...)
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against recombinant human I-kappa-B-kinase betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50124308(N-{3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin...)
Affinity DataIC50: 600nMAssay Description:In vitro inhibitory concentration required against recombinant human IkB kinase beta (IKK-beta)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Kyoto 619-0216

Curated by ChEMBL
LigandPNGBDBM50124308(N-{3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
LigandPNGBDBM50124308(N-{3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human IKK-alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
LigandPNGBDBM50124308(N-{3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human mitogen-activated protein kinase kinase 4 (MKK4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed