BDBM50123044 5-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)-N-(6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-2-hydroxybenzamide::5-[2,6-Dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-phenoxy]-N-(6,6-dimethyl-bicyclo[3.1.1]hept-2-yl)-2-hydroxy-benzamide::CHEMBL124205

SMILES CC1(C)C2CC1C(CC2)NC(=O)c1cc(Oc2c(Cl)cc(cc2Cl)-n2ncc(=O)[nH]c2=O)ccc1O

InChI Key InChIKey=VLJGQKSFQGNOAP-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50123044   

TargetThyroid hormone receptor alpha(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123044(5-[2,6-Dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4...)
Affinity DataEC50:  12nMAssay Description:Effective concentration binding towards TRalpha in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of Insubria

Curated by ChEMBL
LigandPNGBDBM50123044(5-[2,6-Dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4...)
Affinity DataIC50: 0.112nMAssay Description:Inhibition of human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of Insubria

Curated by ChEMBL
LigandPNGBDBM50123044(5-[2,6-Dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4...)
Affinity DataIC50: 0.112nMAssay Description:Inhibition of human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of Insubria

Curated by ChEMBL
LigandPNGBDBM50123044(5-[2,6-Dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4...)
Affinity DataKi:  0.0400nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of Insubria

Curated by ChEMBL
LigandPNGBDBM50123044(5-[2,6-Dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory activity against [125I]T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed