BDBM50122763 4-(2-Methyl-thiazol-4-ylethynyl)-pyridine::CHEMBL303090

SMILES Cc1nc(cs1)C#Cc1ccncc1

InChI Key InChIKey=WWKCHJLBBNNNCI-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50122763   

TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122763(4-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)
Affinity DataIC50: 122nMAssay Description:Tested in vitro against human recombinant Metabotropic glutamate receptor 5 stably expressed in LtK cells by [Ca2+] flux assay using glutamate as ant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122763(4-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)
Affinity DataIC50: 127nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122763(4-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)
Affinity DataKi:  214nMAssay Description:Tested for displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl) pyridine from Metabotropic glutamate receptor 5 in rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122763(4-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)
Affinity DataKi:  218nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed