BDBM50121025 (E)-1-[2,4-Dihydroxy-5-(3-methyl-but-2-enyl)-phenyl]-3-(3,4-dihydroxy-phenyl)-propenone::CHEMBL115452::broussochalcone::broussochalcone A::med.21724, Compound 177

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1cc(-[#6](=O)\[#6]=[#6]\c2ccc(-[#8])c(-[#8])c2)c(-[#8])cc1-[#8]

InChI Key InChIKey=VRSMHXZLVFFWAH-UHFFFAOYSA-N

Data  1 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50121025   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50121025(broussochalcone A | (E)-1-[2,4-Dihydroxy-5-(3-meth...)
Affinity DataIC50: 3.68E+4nMAssay Description:The inhibitory activity tested against human Protein-tyrosine phosphatase 1B enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50121025(broussochalcone A | (E)-1-[2,4-Dihydroxy-5-(3-meth...)
Affinity DataIC50: 2.15E+4nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
University of Nis

Curated by ChEMBL
LigandPNGBDBM50121025(broussochalcone A | (E)-1-[2,4-Dihydroxy-5-(3-meth...)
Affinity DataIC50: 600nMAssay Description:Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate measured at every 1 mins up to 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1a(SARS-CoV)
University of Bonn

LigandPNGBDBM50121025(broussochalcone A | (E)-1-[2,4-Dihydroxy-5-(3-meth...)
Affinity DataIC50: 9.20E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(MERS-CoV)
University of Bonn

LigandPNGBDBM50121025(broussochalcone A | (E)-1-[2,4-Dihydroxy-5-(3-meth...)
Affinity DataIC50: 4.21E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetAlpha-glucosidase MAL62(Baker's yeast)TBA
LigandPNGBDBM50121025(broussochalcone A | (E)-1-[2,4-Dihydroxy-5-(3-meth...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetAmine oxidase [flavin-containing] A(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50121025(broussochalcone A | (E)-1-[2,4-Dihydroxy-5-(3-meth...)
Affinity DataIC50: 720nMAssay Description:Inhibition of human MAO-A using kynuramine as substrate incubated for 20 mins by fluorescence based assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50121025(broussochalcone A | (E)-1-[2,4-Dihydroxy-5-(3-meth...)
Affinity DataIC50: 7.02E+3nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 20 mins by fluorescence based assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
University of Nis

Curated by ChEMBL
LigandPNGBDBM50121025(broussochalcone A | (E)-1-[2,4-Dihydroxy-5-(3-meth...)
Affinity DataIC50: 600nMAssay Description:Inhibition of XO (unknown origin) using xanthine as substrate incubated for 5 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetMaltase-glucoamylase(Human)
Shiv Nadar University

Curated by ChEMBL
LigandPNGBDBM50121025(broussochalcone A | (E)-1-[2,4-Dihydroxy-5-(3-meth...)
Affinity DataKi:  5.30E+3nMAssay Description:Non-competitive inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl-alpha-D glucopyranoside as substrate incubated for 30 mins by Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed