BDBM50120437 CHEMBL3617973

SMILES CN1[C@@H](C(C#N)=C(C)N(C1=O)c1cccc(c1)C(F)(F)F)c1ccc(cc1S(C)(=O)=O)C#N

InChI Key InChIKey=YAJWYFPMASPAMM-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50120437   

TargetNeutrophil elastase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50120437(CHEMBL3617973)
Affinity DataIC50: 0.0650nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50120437(CHEMBL3617973)
Affinity DataIC50: 0.0650nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate measured after 60 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50120437(CHEMBL3617973)
Affinity DataIC50: 0.0650nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNeutrophil elastase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50120437(CHEMBL3617973)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50120437(CHEMBL3617973)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of human Neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed