BDBM50117925 1-(4-fluorobenzyl)-N-(piperidin-4-yl)-1H-benzo[d]imidazol-2-amine::CHEMBL61301::Norastemizole::Tecastemizole::[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-yl]-piperidin-4-yl-amine::[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-yl]-piperidin-4-yl-amine(Norastemizole)::[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-yl]-piperidin-4-yl-amine;2HBr

SMILES Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc23)cc1

InChI Key InChIKey=SFOVDSLXFUGAIV-UHFFFAOYSA-N

Data  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50117925   

LigandPNGBDBM50117925(1-(4-fluorobenzyl)-N-(piperidin-4-yl)-1H-benzo[d]i...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2012
Entry Details Article
PubMed
LigandPNGBDBM50117925(1-(4-fluorobenzyl)-N-(piperidin-4-yl)-1H-benzo[d]i...)
Affinity DataIC50: 28nMAssay Description:K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50117925(1-(4-fluorobenzyl)-N-(piperidin-4-yl)-1H-benzo[d]i...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open stateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
LigandPNGBDBM50117925(1-(4-fluorobenzyl)-N-(piperidin-4-yl)-1H-benzo[d]i...)
Affinity DataIC50: 28.2nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50117925(1-(4-fluorobenzyl)-N-(piperidin-4-yl)-1H-benzo[d]i...)
Affinity DataIC50: 28.2nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50117925(1-(4-fluorobenzyl)-N-(piperidin-4-yl)-1H-benzo[d]i...)
Affinity DataIC50: 27.5nMAssay Description:Inhibition of human ERG channel in HEK293 cells by voltage-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50117925(1-(4-fluorobenzyl)-N-(piperidin-4-yl)-1H-benzo[d]i...)
Affinity DataKd:  1.00E+5nMAssay Description:Binding affinity to Nurr1 (unknown origin) by 1H-STD-NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed